• Users Online: 662
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2018  |  Volume : 30  |  Issue : 2  |  Page : 76-86

Biological response modifiers in Ophthalmology: New horizons, new challenges and new hopes

Assistant Professor of Ophthalmology, Department of Surgery, College of Medicine, King Faisal University, Al Ahsa, Saudi Arabia

Correspondence Address:
Kaberi Biswas Feroze
Faculty of Ophthalmology, College of Medicine, King Faisal University, Al-Ahsa
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/kjo.kjo_46_18

Rights and Permissions

“Biologic response modifier”(BRM) treatment refers to the treatment of human diseases with a diverse group of agents which are generated from living cells, and which act on the immune system, altering the body's immune response. The principal mechanism of action of these agents includes immunomodulation, interference with cellular proliferation, and direct toxic action on cells. They are designed targeted to specific genes or protein receptors, thus making their mechanisms highly attractive as they act on individual entities in the inflammatory pathway. In ophthalmology, biological response modifiers are being studied for use in the treatment of conditions such as noninfectious uveitis, scleritis, Sjogren syndrome, ocular cicatricial pemphigoid, macular edema, idiopathic inflammatory pseudotumors, Behcet's disease, ocular surface disorders, neovascular disorders, and intraocular lymphoma to name a few. BRMs represent a novel and highly exciting mode of therapeutic intervention in some ocular conditions, especially those resistant to conventional treatment. Although newer molecules are being discovered, a lot of research is still needed to evaluate the long-term efficacy and the safety profile of these agents.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded395    
    Comments [Add]    

Recommend this journal